
Hajialyani M, Hosein Farzaei M, Echeverría J, Nabavi SM, Uriarte E, Sobarzo-Sánchez E. Flavonoids in hypertension: a brief review of the underlying mechanisms. Maaliki D, Shaito AA, Pintus G, El-Yazbi A, Eid AH. Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability.

Mas-Capdevila A, Teichenne J, Domenech-Coca C, et al. Anticoagulant and antiplatelet activity of aqueous extracts of Citrus sinensis and Lippia alba : interactions and potential for the development of antithrombotics. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator.
#HESPERIDES CANNABIS TRIAL#
Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). Valls RM, Pedret A, Calderón-Pérez L, et al. Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial. Hesperidin supplementation modulates inflammatory responses following myocardial infarction. Haidari F, Heybar H, Jalali MT, Ahmadi Engali K, Helli B, Shirbeigi E. If you undergo chemotherapy, please consult your oncologist before starting a hesperidin or other supplements. Daunomycin (also called daunorubicin): Hesperidin also interacts with daunomycin (anticancer drug) by increasing drug uptake.Vincristine (anticancer drug): Hesperetin, but not hesperidin, increased vincristine uptake.Due to the overlapping mode of action and potential additive effect, calcium channel blockers should not be taken with hesperidin. Calcium channel blockers: In a rat study, hesperetin reduced calcium concentration, producing a relaxant effect in blood vessels.

Therefore, taking hesperidin with blood pressure-lowering medications may cause an additive effect.
#HESPERIDES CANNABIS PLUS#

Prehypertension or stage 1 hypertension: 500 mL per day of orange juice containing 345 mg per day of hesperidin (the natural hesperidin content) or enriched orange juice containing 600 mg per day of hesperidin for 12 weeks.
